Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis
نویسندگان
چکیده
منابع مشابه
Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
Skin homeostasis is maintained by the continuous proliferation and differentiation of epidermal cells. The skin forms a strong but flexible barrier against microorganisms as well as physical and chemical insults; however, the physiological mechanisms that maintain this barrier are not fully understood. Here, we have described a mutant mouse that spontaneously develops pruritic dermatitis as the...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci82887